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Data Inventory

Welcome to the HELIX project.

The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain, and the United Kingdom). HELIX used a multilevel study design with the entire study population totaling 31,472 mother–child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level); and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). For more details on the study design see Vrijheid, Slama, et al. EHP 2014.


HELIX design picture
Vrijheid, Slama, et al, Environ Health Perspect
2014;122(6):535-44.

If you wish to obtain HELIX data, follow the HELIX Data External Data Request Procedures, starting with the submission of a request form provided to Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.">

To get a first idea of the data available start here: Data overview of the whole project below.
The harmonised datasets (in bold font in the table below) can be found in the codebooks here:Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.
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- Entire cohort - Pregnancy period
- Subcohort - Childhood 6-11 yrsEsta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.">

Entire cohort n~32,000 Subcohort N=1301 Panel study n~150
Pregnancy Postnatal 0-8 yrs Pregnancy Childhood 6-11 yrs Pregnancy Children
Contaminant exposures Tobacco smoke Tobacco smoke (in preparation) Tobacco smoke Tobacco smoke



Water disinfection Byproducts Water disinfection Byproducts Indoor air (BTEX, NO2, PM2.5)
Organochlorine compounds
Brominated compounds
Perfluorinated alkylated substances (PFAS)
Metals and elements
Phthalate metabolites
Phenols
Organophosphate pesticide metabolites
Organochlorine compounds
Brominated compounds
Perfluorinated alkylated substances (PFAS)
Metals and elements
Phthalate metabolites
Phenols
Organophosphate pesticide metabolites
-4 separate days in one study period: Phthalates, phenols, organophosphate pesticides
- One pool in each of the two study periods: Phthalates, phenols, organophosphate pesticides, cotinine
Phthalates
- 7 days in one study period Phthalates

-4 separate days in one study period: Phthalates, phenols, organophosphate pesticides
- One pool in each of the two study periods: Phthalates, phenols, organophosphate pesticides, cotinine
Phthalates
- 7 days in one study period Phthalates
Lifestyle Dietary Habits Dietary Habits  Dietary Habits Dietary Habits
Physical activity Physical activity Physical activity Physical activity Physical activity
Sleep duration
To be harmonised: Pet ownership and allergens
gas cooking
Mold
transport
time activity
Pet ownership and allergens
Outdoor and urban exposures Air pollution
Traffic noise
UV
Temperature
Built envt.
Traffic
Natural spaces
Air pollution
Traffic noise
UV
Temperature
Built envt.
Traffic
Natural spaces
Air pollution
Traffic noise
UV
Temperature
Built envt.
Traffic
Natural spaces
Air pollution
Traffic noise
UV
Temperature
Built envt.
Traffic
Natural spaces
Geolocation and mobility
NO2
BTEX(benzene, toluene, ethylene, and m,p,o-xylene)
PM2.5
Black carbon
UV
Geolocation and mobility
NO2
BTEX(benzene, toluene, ethylene, and m,p,o-xylene)
PM2.5
Black carbon
UV
Omics analyses Proteomics
Methylation
Transcriptomics
miRNA
Urinary metabolomics
Serum metabolomics
Telomere length
Age accelaration score
  Proteomics
Methylation
Transcriptomics
miRNA
Urinary metabolomics 
Serum metabolomics
Telomere length
Age accelaration score
Genome (coming 2018-19)
Clinical outcomes Gestational age; Birth weight To be harmonised
BMI
Growth and obesity
Blood pressure
Neurodevelopment
Asthma/Wheeze
Gestational age; Birth weight BMI
Growth and obesity
Blood pressure
Neurodevelopment
Respiratory&Allergy
Lung function test
birth weight, blood pressure  Lung function
Blood pressure
Height and weight
(Last day of period 1 and 2) + same variables as subcohort for period 1
Other Variables - Pregnancy history; Pregnancy complications; Birth outcomes; Parental weight/height; Alcohol consumption; SES - Pregnancy history; Birth info; Parental weight/height;
- Smoking; Alcohol;
- Other questionnaire data: participants info and siblings, sleep patterns, family wealth, social capital, maternal perceived stress, home environment, cooking and heating, cleaning products, noise, water use (drinking, personal hygiene and swimming), use of mobile phones and new technologies, sunlight exposure, puberty - Questionnaire - Questionnaire week 1
Ethnicity Ethnicity - Questionnaire week 2
SES: - Income and occupation (only for some cohorts)
- Area-level deprivation index
- Area-level deprivation index SES: - Income and occupation (only for some cohorts)
- Area-level deprivation index
- Social capital and familly affluence
- Area-level deprivation index
Maternal cognition (n-back test)
Sample collection info Sample collection info

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