Publications
Wednesday, 16 May 2018 13:39
Newsbriefing - May 2018
Following the final HELIX Scientific Symposium last October, and the official closure of the project in December, the HELIX Consortium continues to be busy!Find here and update of our activities, reports, publications, and most exiting - The HELIX Database!
Wednesday, 16 May 2018 10:08
HELIX Scientific Symposium 2017 - Report
The final scientific symposium of the HELIX project took place on 30-31 October 2017 in Barcelona, Spain. This was the final meeting where the project consortium and stakeholders came together to discuss the key successes of the project studies, and translation of the results into future action at scientific and…
Monday, 11 December 2017 16:22
Scientific Publications
Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment The risk of obesity can be different for boys and girls in certain prenatal environments. We identified an environment combining four exposure levels that protect girls from obesity and neurodevelopment delay. The combination of single exposures into multiexposure…
Friday, 04 August 2017 08:00
New HELIX Publication: A systematic comparison of statistical methods to detect interactions in exposome-health associations.
There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept. Uncovering such combined effects is challenging owing to the large number of exposures, several of them being highly correlated. This paper describes a…
Wednesday, 17 May 2017 13:38
Project Update - May 2017
With the start of summer in sight, HELIX will soon arrive at the completion of the second official part of the project – data generation and analysis. However, we are not done just yet! To allow us to present to you a most comprehensive set of results and associated implications,…
Tuesday, 16 May 2017 09:25
HELIX explanatory video
We are pleased to present a short video in which our researchers explain how the HELIX project teaches us more about the environment-physical health relationship. In all, we hope to contribute to improving preventive disease strategies, which leads to lower health costs and a reduction of the environmental burden of…
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Thursday, 04 May 2017 13:20
MultiDataSet: an R package for encapsulating multiple data sets with application to omic data integration
Reduction in the cost of genomic assays has generated large amounts of biomedical-related data. As a result, current studies perform multiple experiments in the same subjects. While Bioconductor’s methods and classes implemented in different packages manage individual experiments, there is not a standard class to properly manage different omic datasets…
Friday, 28 April 2017 09:29
HELIX Scientific Paper: "Assessment of metabolic phenotypic variability in children’s urine using 1 H NMR spectroscopy"
This study focuses on 1 H NMR spectroscopic analyses of urine, which in comparison to blood is a non-invasive biofluid to access, making it a more attractive choice for large-scale biological sampling in children. The influence of the sample collection time-point of the day on the metabolic phenotype was examined,…
Thursday, 17 November 2016 09:44
Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study
Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. This study characterizes the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two Spanish subcohorts. It further explains potential sources of variation in metabolic profiles based on lifestyle and…
Tuesday, 09 August 2016 14:23
Health is Global - The Exposome: Understanding the Effect of the Environment on Our Health
Published on 8 August 2016 on the Health is Global Blog. In "The Exposome: Understanding the Effect of the Environment on Our Health", Lea Maitre of ISGlobal describes the origin and development of the exposome and the HELIX project.
Thursday, 23 June 2016 11:23
HELIX conference posters
Rexposome: A bioinformatic tool for characterizing multiple environmental factors and its association with different omics biomarkers and disease. Emory Exposome Summer Course, Atlanta, 2016.Rexposome: A bioinformatic tool for characterizing multiple environmental factors and its association with different omics biomarkers and disease. XIII Symposium on Bioinformatics, Valencia, 2016.
Tuesday, 22 September 2015 16:54
Exposing the Exposome - H2020 News
We know a lot about the human genome and the role genes play in disease. But environmental factors could play an even more important role than genetics. H2020 News today published an article on how the EU-funded HELIX researchers are helping to put together a so-called exposome to characterise the…
Monday, 07 September 2015 08:56
Cohorte Sépages - Les Bébés Alertés (video)
Dans quatre maternités de Grenoble dont celle du CHU, une ambitieuse étude menée sur une cohorte de 700 femmes enceintes mesure leur exposition aux particules fines. Cette étude, appelée Sépages, a pour ambition de retracer l'impact de l'environnement sur la grossesse et sur la santé des bébés. Elle doit se…
Tuesday, 02 June 2015 11:35
How lifestyle factors and pollution may affect child and future health
[Press Release]Children and pregnant women are contributing to the large Europe-wide HELIX project to build an early-life “exposome” for studying many environmental influences on health, focusing on obesity, asthma and neurodevelopment. Barcelona, June 2nd 2015 – Pregnancy and the early years of life are well recognized to be periods of…
