- What we do
- Project management
In six existing prospective birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures: persistent and non-persistent organic chemicals, metals, pesticides, environmental tobacco smoke, water contaminants, air pollutants, noise, UV radiation, and contact with green spaces.
Exposure models will be developed for the full cohorts totalling 32,000 mother-child pairs and biomarkers will be measured in a subset of 1,200.
Nested repeat-sampling panel studies (N=150) will collect data on biomarker variability and use smartphone-linked sensors to assess individual mobility, physical activity and personal exposure to air pollutants and UV radiation.
Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple and combined exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes.
Finally, a health impact assessment exercise will be conducted for combined early-life exposures.
Martine Vrijheid - mvrijheid[at]creal.catProject Coordinator
Diana van Gent - dvangent[at]creal.catProject Manager and contact
CREAL - Centre de Recerca en Epidemiologia Ambiental
Parc Recerca Biomèdica de BarcelonaDoctor Aiguader, 88 - 08003, Barcelona
Tel +34 932 14 7354
Fax +34 932 14 7301